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There is insufficient comparative evidence both for dantrolene and for the skeletal muscle relaxants which have not been FDA-approved to treat spasticity.[full review]In patients with acute back pain or neck pain, cyclobenzaprine is consistently more effective than placebo for relieving pain, treating muscle spasms, and increasing function.

Many different classes of drugs, from antidepressants to benzodiazepines to antiepileptics, are also used to treat painful muscle spasms, but are not classified as skeletal muscle relaxants or approved for this indication by the FDA.Muscle spasms can be caused by musculoskeletal conditions, such as back pain and neck pain, or neurological conditions associated with upper motor neuron lesions, such as multiple sclerosis.Both underlying causes can result in localized tenderness, significant pain, limitation of movement, and disability.Adverse effects, particularly dizziness and drowsiness, are consistently reported with all skeletal muscle relaxants.The potential adverse effects should be communicated clearly to the patient.

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